Repaglinide pre-meal tablet doses and daily dose maximums for the GPhC assessment

The manufacturer's UK product information for repaglinide tablets states that repaglinide is given preprandially and is titrated individually to optimise glycaemic control, that the recommended starting dose is 0.5 mg, and that one to two weeks should elapse between titration steps, determined by blood glucose response.

The same information states that if patients are transferred from another oral hypoglycaemic medicinal product, the recommended starting dose is 1 mg, that the recommended maximum single dose is 4 mg taken with main meals, and that the total maximum daily dose should not exceed 16 mg.

It also states that doses are usually taken within 15 minutes of the meal, but the time may vary from immediately preceding the meal to as long as 30 minutes before the meal, preprandially 2, 3, or 4 meals a day, and that patients who skip a meal, or add an extra meal, should be instructed to skip, or add, a dose for that meal.

Each question fixes the values needed for its arithmetic. Write the unit beside every step and distinguish a single pre-meal dose from a daily total or a supply period. All prescriptions and patients here are fictional; these are revision materials, not for patient care.