Common Registration Assessment, Part 1

Itraconazole oral solution volumes and course doses for the GPhC assessment

Three original practice questions, with the working shown. Read the stated prescription or plan before calculating.

Published 7 November 2026. Independent revision material, not GPhC questions, not for patient care.

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The manufacturer's UK product information for itraconazole 10 mg/ml oral solution states that for oral or oesophageal candidosis the dose is 200 mg (20 ml) per day, in one or two intakes, for one week, continued for another week if there is no response.

The same information states that for fluconazole-resistant oral or oesophageal candidosis the dose is 100 to 200 mg (10 to 20 ml) twice daily for two weeks, and that the 400 mg (40 ml) daily dose should not be used for longer than 14 days if there are no signs of improvement.

It also states that for prophylaxis of fungal infections the dose is 5 mg/kg (0.5 ml/kg) per day in two intakes, and that the solution should be taken without food.

Each question fixes the values needed for its arithmetic. Write the unit beside every step and distinguish a single dose from a daily total or a supply period. All prescriptions and patients here are fictional; these are revision materials, not for patient care.

The method

  1. Identify the stated dose in milligrams or in millilitres, and the frequency per day.
  2. Convert between milligrams and millilitres using the stated 10 mg/ml strength.
  3. Multiply the daily volume by the stated number of days for a course quantity.
  4. Keep milligrams, millilitres and days separate; convert only when the question asks.

Three practice questions

Work each one on paper first, then open the answer. All patients and prescriptions are fictional.

Question 1

A fictional patient takes itraconazole oral solution 200 mg per day for 7 days for oral candidosis. The solution contains 10 mg/ml. How many millilitres is the course?

Show the answer

Answer: 140 ml

Working: 200 mg / 10 mg per ml = 20 ml each day. 20 ml x 7 days = 140 ml.

Question 2

A fictional patient takes itraconazole oral solution 10 ml twice daily for 14 days for fluconazole-resistant candidosis. How many millilitres and how many milligrams is the course?

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Answer: 280 ml (2,800 mg)

Working: 10 ml x 2 intakes = 20 ml each day. 20 ml x 14 days = 280 ml. 20 ml x 10 mg per ml = 200 mg each day, and 200 mg x 14 days = 2,800 mg.

Question 3

A fictional patient weighs 60 kg and takes itraconazole oral solution for prophylaxis at 0.5 ml/kg per day in two intakes. How many millilitres is each intake?

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Answer: 15 ml

Working: 0.5 ml x 60 kg = 30 ml each day. 30 ml / 2 intakes = 15 ml per intake.

eMC SmPC: Itraconazole 10mg/ml Sugar Free Oral Solution

https://www.medicines.org.uk/emc/product/10049/smpc

Where marks are lost

  • Converting milligrams to millilitres without using the stated 10 mg per ml strength.
  • Treating 20 ml per day as 20 ml per intake when the day is split into two intakes.
  • Extending the 400 mg daily dose beyond 14 days when the product information limits it to 14 days without improvement.

Frequently asked questions

Are these official assessment questions?

No. They are original revision exercises, not official GPhC questions and not for patient care.

Does this calculation decide a real itraconazole course?

No. Follow the stated prescription in the exercise. Real courses depend on the infection, response and other medicines, and the solution is taken without food.

How should I check the answer?

Check the requested unit, then convert between milligrams and millilitres using the stated 10 mg per ml before totalling.

Sources

The questions above are original and use fictional patients and prescriptions. PreRegExamPrep is not affiliated with or endorsed by the General Pharmaceutical Council.

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More calculation topics

See also the formula sheet, the eight sample questions and the approved calculator page.