Tizanidine divided daily doses and weekly titration steps for the GPhC assessment

The manufacturer's UK product information for tizanidine 4 mg tablets states that for spasms of the skeletal muscles the recommended dose is 2 to 4 mg three times daily, and that in severe cases an extra dose of 2 to 4 mg may be given, preferably late in the evening to reduce the sedative effect.

The same information states that for spasticity due to neurological disorders the initial daily dose should not exceed 6 mg in 3 divided doses, that the dose may be increased in steps of 2 to 4 mg at intervals of half or full week, that the optimum therapeutic response is usually achieved with a daily dose of between 12 and 24 mg divided into 3 to 4 equal doses, and that the total daily dose should not exceed 36 mg.

It also states that tizanidine has a narrow therapeutic index and that the dose should be increased gradually and with caution.

Each question fixes the values needed for its arithmetic. Write the unit beside every step and distinguish a single dose from a daily total or a supply period. All prescriptions and patients here are fictional; these are revision materials, not for patient care.