Pramipexole microgram tablets and weekly titration steps for the GPhC assessment

The manufacturer's UK product information for MIRAPEXIN tablets gives an ascending dose schedule for adults with Parkinson's disease: week 1 is 3 x 0.088 mg of base a day (0.264 mg a day) and week 2 is 3 x 0.18 mg of base a day (0.54 mg a day). For week 3 it lists 3 x 0.35 mg of base and a rounded daily figure of 1.1 mg. Multiplying the displayed tablet strength gives 1.05 mg; do not use the rounded table figure as an exact arithmetic equality.

The same information states that if a further increase is needed, the daily dose should be increased by 0.54 mg of base at weekly intervals up to a maximum of 3.3 mg of base a day.

Doses are taken three times a day in equally divided doses, and the product information uses both base and salt figures; these exercises use the base figures. Kidney function can require lower doses and a different frequency; the three-times-daily schedule is not universal.

Each question fixes the values needed for its arithmetic. Write the unit beside every step and keep micrograms and milligrams straight. All prescriptions and patients here are fictional; these are revision materials, not for patient care.