Leflunomide loading dose and 10mg 20mg maintenance tablets for the GPhC assessment

The manufacturer's UK product information for leflunomide tablets states that in rheumatoid arthritis, therapy is usually started with a loading dose of 100 mg once daily for 3 days, and that the recommended maintenance dose is 10 mg to 20 mg once daily depending on the severity of the disease.

The same information states that in psoriatic arthritis, therapy is started with the same loading dose of 100 mg once daily for 3 days, followed by a recommended maintenance dose of 20 mg once daily, and that the therapeutic effect usually starts after 4 to 6 weeks and may further improve up to 4 to 6 months.

It also states that ALT and a complete blood cell count must be checked before initiation, every two weeks during the first six months of treatment, and every 8 weeks thereafter.

Each question fixes the values needed for its arithmetic. Write the unit beside every step and distinguish a single dose from a daily total or a supply period. All prescriptions and patients here are fictional; these are revision materials, not for patient care.